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inter-protomer interfaces control gating of a mammalian TRPM5 channel. Proceedings of the National

Academy of Sciences, Vol. 121, No. 27, 10.1073/pnas.2403333121

Spaulding Z, Thevarajan I, Schrag LG, Zubcevic L, Zolkiewska A, Zolkiewski M.

Human mitochondrial AAA+ ATPase SKD3/CLPB assembles into nucleotide-stabilized

dodecamers. Biochem Biophys Res Commun. 2022 Apr 30;602:21-26. doi:

10.1016/j.bbrc.2022.02.101. Epub 2022 Feb 25. PMID: 35247700; PMCID: PMC8957611.

Zubcevic L. Preparation of the Transient Receptor Potential Vanilloid 2

(TRPV2) channel for structural studies. Methods Enzymol. 2021;653:21-48. doi:

10.1016/bs.mie.2020.12.002. Epub 2021 Jan 18. PMID: 34099173.

Zubcevic L. Temperature-sensitive transient receptor potential vanilloid

channels: structural insights into ligand-dependent activation. Br J Pharmacol.

2022 Jul;179(14):3542-3559. doi: 10.1111/bph.15310. Epub 2020 Nov 26. PMID:

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Zubcevic L. TRP Channels, Conformational Flexibility, and the Lipid Membrane.

J Membr Biol. 2020 Aug;253(4):299-308. doi: 10.1007/s00232-020-00127-0. Epub

2020 Jun 29. PMID: 32601711.

Suo Y, Wang Z, Zubcevic L, Hsu AL, He Q, Borgnia MJ, Ji RR, Lee SY.

Structural Insights into Electrophile Irritant Sensing by the Human TRPA1

Channel. Neuron. 2020 Mar 4;105(5):882-894.e5. doi:

10.1016/j.neuron.2019.11.023. Epub 2019 Dec 19. PMID: 31866091; PMCID:

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Zubcevic L, Lee SY. The role of π-helices in TRP channel gating. Curr Opin

Struct Biol. 2019 Oct;58:314-323. doi: 10.1016/j.sbi.2019.06.011. Epub 2019 Aug

2. PMID: 31378426; PMCID: PMC6778516.

Zubcevic L, Hsu AL, Borgnia MJ, Lee SY. Symmetry transitions during gating of

the TRPV2 ion channel in lipid membranes. Elife. 2019 May 15;8:e45779. doi:

10.7554/eLife.45779. PMID: 31090543; PMCID: PMC6544438.

Zubcevic L, Borschel WF, Hsu AL, Borgnia MJ, Lee SY. Regulatory switch at the

cytoplasmic interface controls TRPV channel gating. Elife. 2019 May 9;8:e47746.

doi: 10.7554/eLife.47746. PMID: 31070581; PMCID: PMC6538378.

Zubcevic L, Herzik MA Jr, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC,

Lee SY. Conformational ensemble of the human TRPV3 ion channel. Nat Commun. 2018

Nov 14;9(1):4773. doi: 10.1038/s41467-018-07117-w. PMID: 30429472; PMCID:

PMC6235889.

Zubcevic L, Le S, Yang H, Lee SY. Conformational plasticity in the

selectivity filter of the TRPV2 ion channel. Nat Struct Mol Biol. 2018

May;25(5):405-415. doi: 10.1038/s41594-018-0059-z. Epub 2018 Apr 30. PMID:

29728656; PMCID: PMC6025827.

Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY. Structure of the

cold- and menthol-sensing ion channel TRPM8. Science. 2018 Jan

12;359(6372):237-241. doi: 10.1126/science.aan4325. Epub 2017 Dec 7. PMID:

29217583; PMCID: PMC5810135.

Zubcevic L, Herzik MA Jr, Chung BC, Liu Z, Lander GC, Lee SY. Cryo-electron

microscopy structure of the TRPV2 ion channel. Nat Struct Mol Biol. 2016

Feb;23(2):180-186. doi: 10.1038/nsmb.3159. Epub 2016 Jan 18. PMID: 26779611;

PMCID: PMC4876856.

Zubcevic L, Wang S, Bavro VN, Lee SJ, Nichols CG, Tucker SJ. Modular Design

of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward

Rectifier' (NirBac) channels. Sci Rep. 2015 Oct 16;5:15305. doi:

10.1038/srep15305. PMID: 26470642; PMCID: PMC4607889.

Zubcevic L, Bavro VN, Muniz JR, Schmidt MR, Wang S, De Zorzi R, Venien-Bryan

C, Sansom MS, Nichols CG, Tucker SJ. Control of KirBac3.1 potassium channel

gating at the interface between cytoplasmic domains. J Biol Chem. 2014 Jan

3;289(1):143-51. doi: 10.1074/jbc.M113.501833. Epub 2013 Nov 20. PMID: 24257749;

PMCID: PMC3879539.

Bavro VN, De Zorzi R, Schmidt MR, Muniz JR, Zubcevic L, Sansom MS, Vénien-

Bryan C, Tucker SJ. Structure of a KirBac potassium channel with an open bundle

crossing indicates a mechanism of channel gating. Nat Struct Mol Biol. 2012 Jan

8;19(2):158-63. doi: 10.1038/nsmb.2208. PMID: 22231399; PMCID: PMC3272479.

Shimomura K, Flanagan SE, Zadek B, Lethby M, Zubcevic L, Girard CA, Petz O,

Mannikko R, Kapoor RR, Hussain K, Skae M, Clayton P, Hattersley A, Ellard S,

Ashcroft FM. Adjacent mutations in the gating loop of Kir6.2 produce neonatal

diabetes and hyperinsulinism. EMBO Mol Med. 2009 Jun;1(3):166-77. doi:

10.1002/emmm.200900018. PMID: 20049716; PMCID: PMC3378123.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P,

Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill

A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM. Expression of an

activating mutation in the gene encoding the KATP channel subunit Kir6.2 in

mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest. 2009

Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8. PMID: 19065048; PMCID:

PMC2613450.

Staník J, Lethby M, Flanagan SE, Gasperíková D, Milosovicová B, Lever M,

Bullman H, Zubcevic L, Hattersley AT, Ellard S, Ashcroft FM, Klimes I.

Coincidence of a novel KCNJ11 missense variant R365H with a paternally inherited

6q24 duplication in a patient with transient neonatal diabetes. Diabetes Care.

2008 Sep;31(9):1736-7. doi: 10.2337/dc08-0549. Epub 2008 Jun 12. PMID: 18556340;

PMCID: PMC2518334.

Mlynarski W, Tarasov AI, Gach A, Girard CA, Pietrzak I, Zubcevic L,

Kusmierek J, Klupa T, Malecki MT, Ashcroft FM. Sulfonylurea improves CNS

function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11.

Nat Clin Pract Neurol. 2007 Nov;3(11):640-5. doi: 10.1038/ncpneuro0640. PMID:

17982434.

Ma X, Zubcevic L, Brüning JC, Ashcroft FM, Burdakov D. Electrical inhibition

of identified anorexigenic POMC neurons by orexin/hypocretin. J Neurosci. 2007

Feb 14;27(7):1529-33. doi: 10.1523/JNEUROSCI.3583-06.2007. PMID: 17301161;

PMCID: PMC6673748.